Title |
Infection with the Lyme disease pathogen suppresses innate immunity in mice with diet-induced obesity
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Published in |
Cellular Microbiology, November 2016
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DOI | 10.1111/cmi.12689 |
Pubmed ID | |
Authors |
Nataliya Zlotnikov, Ashkan Javid, Mijhgan Ahmed, Azad Eshghi, Tian Tian Tang, Anoop Arya, Anil Bansal, Fatima Matar, Maitry Parikh, Rhodaba Ebady, Adeline Koh, Nupur Gupta, Peng Song, Yang Zhang, Susan Newbigging, Gary P. Wormser, Ira Schwartz, Robert Inman, Michael Glogauer, Tara J. Moriarty |
Abstract |
Obesity is a major global public health concern. Immune responses implicated in obesity also control certain infections. We investigated the effects of high fat diet (HFD)-induced obesity (DIO) on infection with the Lyme disease bacterium Borrelia burgdorferi in mice. DIO was associated with systemic suppression of neutrophil- and macrophage-based innate immune responses. These included bacterial uptake and cytokine production, and systemic, progressive impairment of bacterial clearance and increased carditis severity. B. burgdorferi-infected mice fed normal diet also gained weight at the same rate as uninfected mice fed HFD, Toll-like receptor 4 deficiency rescued bacterial clearance defects, which were greater in females than males, and killing of an unrelated bacterium (Escherichia coli) by bone marrow-derived macrophages from obese, B. burgdorferi-infected mice was also affected. Importantly, innate immune suppression increased with infection duration and depended on cooperative and synergistic interactions between DIO and B. burgdorferi infection. Thus, obesity and B. burgdorferi infection cooperatively and progressively suppressed innate immunity in mice. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 13% |
Canada | 4 | 10% |
United Kingdom | 3 | 8% |
France | 1 | 3% |
Pakistan | 1 | 3% |
Nigeria | 1 | 3% |
Switzerland | 1 | 3% |
Serbia | 1 | 3% |
Mexico | 1 | 3% |
Other | 2 | 5% |
Unknown | 20 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 28 | 70% |
Scientists | 7 | 18% |
Practitioners (doctors, other healthcare professionals) | 3 | 8% |
Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 17% |
Other | 6 | 14% |
Researcher | 6 | 14% |
Professor | 5 | 12% |
Student > Master | 4 | 10% |
Other | 6 | 14% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 11 | 26% |
Medicine and Dentistry | 9 | 21% |
Agricultural and Biological Sciences | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 8 | 19% |
Unknown | 9 | 21% |