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Sox2 promotes tamoxifen resistance in breast cancer cells

Overview of attention for article published in EMBO Molecular Medicine, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Citations

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152 Dimensions

Readers on

mendeley
159 Mendeley
citeulike
1 CiteULike
Title
Sox2 promotes tamoxifen resistance in breast cancer cells
Published in
EMBO Molecular Medicine, October 2013
DOI 10.1002/emmm.201303411
Pubmed ID
Authors

Marco Piva, Giacomo Domenici, Oihana Iriondo, Miriam Rábano, Bruno M Simões, Valentine Comaills, Inmaculada Barredo, Jose A López‐Ruiz, Ignacio Zabalza, Robert Kypta, Maria d M Vivanco

Abstract

Development of resistance to therapy continues to be a serious clinical problem in breast cancer management. Cancer stem/progenitor cells have been shown to play roles in resistance to chemo‐ and radiotherapy. Here, we examined their role in the development of resistance to the oestrogen receptor antagonist tamoxifen. Tamoxifen‐resistant cells were enriched for stem/progenitors and expressed high levels of the stem cell marker Sox2. Silencing of the SOX2 gene reduced the size of the stem/progenitor cell population and restored sensitivity to tamoxifen. Conversely, ectopic expression of Sox2 reduced tamoxifen sensitivity in vitro and in vivo. Gene expression profiling revealed activation of the Wnt signalling pathway in Sox2‐expressing cells, and inhibition of Wnt signalling sensitized resistant cells to tamoxifen. Examination of patient tumours indicated that Sox2 levels are higher in patients after endocrine therapy failure, and also in the primary tumours of these patients, compared to those of responders. Together, these results suggest that development of tamoxifen resistance is driven by Sox2‐dependent activation of Wnt signalling in cancer stem/progenitor cells.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 1%
United Kingdom 1 <1%
Colombia 1 <1%
Netherlands 1 <1%
Mexico 1 <1%
China 1 <1%
Spain 1 <1%
Unknown 151 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 28%
Researcher 32 20%
Student > Master 17 11%
Student > Bachelor 15 9%
Student > Doctoral Student 9 6%
Other 22 14%
Unknown 19 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 55 35%
Biochemistry, Genetics and Molecular Biology 37 23%
Medicine and Dentistry 22 14%
Pharmacology, Toxicology and Pharmaceutical Science 6 4%
Engineering 4 3%
Other 10 6%
Unknown 25 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2018.
All research outputs
#573,082
of 13,336,109 outputs
Outputs from EMBO Molecular Medicine
#125
of 919 outputs
Outputs of similar age
#9,449
of 183,043 outputs
Outputs of similar age from EMBO Molecular Medicine
#8
of 31 outputs
Altmetric has tracked 13,336,109 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 919 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,043 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.