| Title |
Sox2 promotes tamoxifen resistance in breast cancer cells
|
|---|---|
| Published in |
EMBO Molecular Medicine, October 2013
|
| DOI | 10.1002/emmm.201303411 |
| Pubmed ID | |
| Authors |
Marco Piva, Giacomo Domenici, Oihana Iriondo, Miriam Rábano, Bruno M Simões, Valentine Comaills, Inmaculada Barredo, Jose A López‐Ruiz, Ignacio Zabalza, Robert Kypta, Maria d M Vivanco |
| Abstract |
Development of resistance to therapy continues to be a serious clinical problem in breast cancer management. Cancer stem/progenitor cells have been shown to play roles in resistance to chemo‐ and radiotherapy. Here, we examined their role in the development of resistance to the oestrogen receptor antagonist tamoxifen. Tamoxifen‐resistant cells were enriched for stem/progenitors and expressed high levels of the stem cell marker Sox2. Silencing of the SOX2 gene reduced the size of the stem/progenitor cell population and restored sensitivity to tamoxifen. Conversely, ectopic expression of Sox2 reduced tamoxifen sensitivity in vitro and in vivo. Gene expression profiling revealed activation of the Wnt signalling pathway in Sox2‐expressing cells, and inhibition of Wnt signalling sensitized resistant cells to tamoxifen. Examination of patient tumours indicated that Sox2 levels are higher in patients after endocrine therapy failure, and also in the primary tumours of these patients, compared to those of responders. Together, these results suggest that development of tamoxifen resistance is driven by Sox2‐dependent activation of Wnt signalling in cancer stem/progenitor cells. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 20% |
| Peru | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 40% |
| Members of the public | 2 | 40% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | <1% |
| Colombia | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 220 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 23% |
| Researcher | 40 | 18% |
| Student > Bachelor | 22 | 10% |
| Student > Master | 18 | 8% |
| Student > Doctoral Student | 14 | 6% |
| Other | 28 | 12% |
| Unknown | 53 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 25% |
| Biochemistry, Genetics and Molecular Biology | 55 | 24% |
| Medicine and Dentistry | 25 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Engineering | 5 | 2% |
| Other | 17 | 7% |
| Unknown | 63 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2022.
All research outputs
#1,334,337
of 24,626,543 outputs
Outputs from EMBO Molecular Medicine
#290
of 1,575 outputs
Outputs of similar age
#12,353
of 219,034 outputs
Outputs of similar age from EMBO Molecular Medicine
#7
of 28 outputs
Altmetric has tracked 24,626,543 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,575 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,034 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.