Title |
Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia
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Published in |
EMBO Journal, August 2017
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DOI | 10.15252/embj.201796821 |
Pubmed ID | |
Authors |
Roberto Carlos Agís‐Balboa, Paulo S Pinheiro, Nelson Rebola, Cemil Kerimoglu, Eva Benito, Michael Gertig, Sanaz Bahari‐Javan, Gaurav Jain, Susanne Burkhardt, Ivana Delalle, Alexander Jatzko, Markus Dettenhofer, Patricia A Zunszain, Andrea Schmitt, Peter Falkai, Julius C Pape, Elisabeth B Binder, Christophe Mulle, Andre Fischer, Farahnaz Sananbenesi |
Abstract |
Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age. We show that the actin nucleator Formin 2 (Fmn2) is deregulated in PTSD and in Alzheimer's disease (AD) patients. Young mice lacking the Fmn2 gene exhibit PTSD-like phenotypes and corresponding impairments of synaptic plasticity, while the consolidation of new memories is unaffected. However, Fmn2 mutant mice develop accelerated age-associated memory decline that is further increased in the presence of additional risk factors and is mechanistically linked to a loss of transcriptional homeostasis. In conclusion, our data present a new approach to explore the connection between AD risk factors across life span and provide mechanistic insight to the processes by which neuropsychiatric diseases at a young age affect the risk for developing dementia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 25% |
Spain | 2 | 17% |
United Kingdom | 1 | 8% |
Canada | 1 | 8% |
Brazil | 1 | 8% |
Unknown | 4 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 67% |
Scientists | 4 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 87 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 17% |
Researcher | 11 | 13% |
Student > Bachelor | 10 | 11% |
Other | 7 | 8% |
Professor | 5 | 6% |
Other | 14 | 16% |
Unknown | 25 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 27 | 31% |
Agricultural and Biological Sciences | 13 | 15% |
Medicine and Dentistry | 10 | 11% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Psychology | 5 | 6% |
Other | 2 | 2% |
Unknown | 24 | 28% |