| Title |
Cyclic Depsipeptide BE‐43547A2: Synthesis and Activity against Pancreatic Cancer Stem Cells
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, October 2017
|
| DOI | 10.1002/anie.201709744 |
| Pubmed ID | |
| Authors |
Yuanjun Sun, Yahui Ding, Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang, Yue Chen |
| Abstract |
The asymmetric total synthesis of cyclic depsipeptide BE-43547A₂ was achieved in 15 linear steps on a 350 mg scale in one batch. Our synthesis is featured with highly diastereoselective construction of α-hydroxy-β-ketoamide via α-hydroxylation with a d.r. up to 86:1. BE-43547A₂ can significantly reduce the percentage of pancreatic cancer stem cells in Panc-1 cells, and dramatically ablate the tumorsphere forming capability of Panc-1 cells. The tumor-initiating assay in-vivo, a gold standard for cancer stem cell assays, confirmed BE-43547A₂ could abolish the tumorigenesis of Panc-1 cells. The anti-PCSC activity of BE-43547A₂ will make this depsipeptide scaffold a start for discovering new PCSC-targeting drug. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 25% |
| Dominican Republic | 1 | 13% |
| Germany | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 38% |
| Scientists | 3 | 38% |
| Science communicators (journalists, bloggers, editors) | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 25% |
| Student > Bachelor | 2 | 13% |
| Lecturer | 1 | 6% |
| Student > Doctoral Student | 1 | 6% |
| Other | 1 | 6% |
| Other | 3 | 19% |
| Unknown | 4 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 56% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Social Sciences | 1 | 6% |
| Mathematics | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 3 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2017.
All research outputs
#547,828
of 25,530,891 outputs
Outputs from Angewandte Chemie. International Edition
#408
of 50,306 outputs
Outputs of similar age
#11,646
of 338,698 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#9
of 791 outputs
Altmetric has tracked 25,530,891 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50,306 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 791 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.