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The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments

Overview of attention for article published in Febs Letters, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
5 tweeters
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
150 Dimensions

Readers on

mendeley
254 Mendeley
citeulike
1 CiteULike
Title
The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments
Published in
Febs Letters, May 2015
DOI 10.1016/j.febslet.2015.05.037
Pubmed ID
Authors

Thomas Cremer, Marion Cremer, Barbara Hübner, Hilmar Strickfaden, Daniel Smeets, Jens Popken, Michael Sterr, Yolanda Markaki, Karsten Rippe, Christoph Cremer

Abstract

Recent methodological advancements in microscopy and DNA sequencing-based methods provide unprecedented new insights into the spatio-temporal relationships between chromatin and functional nuclear machineries. We discuss a model of functional nuclear organization derived mostly from electron and super-resolved fluorescence microscopy studies. It is based on two spatially co-aligned, active and inactive nuclear compartments (ANC and INC). The INC comprises the compact, transcriptionally inactive core of chromatin domain clusters (CDCs). The ANC is formed by the transcriptionally active periphery of CDCs, called the perichromatin region (PR), and the interchromatin compartment (IC). The IC is connected to nuclear pores and serves nuclear import and export functions. The ANC is the major site of RNA synthesis. It is highly enriched in epigenetic marks for transcriptionally competent chromatin and RNA Polymerase II. Marks for silent chromatin are enriched in the INC. Multi-scale cross-correlation spectroscopy suggests that nuclear architecture resembles a random obstacle network for diffusing proteins. An increased dwell time of proteins and protein complexes within the ANC may help to limit genome scanning by factors or factor complexes to DNA exposed within the ANC.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
France 2 <1%
Czechia 2 <1%
Italy 1 <1%
United Kingdom 1 <1%
Russia 1 <1%
Japan 1 <1%
Germany 1 <1%
Unknown 243 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 68 27%
Researcher 59 23%
Student > Bachelor 30 12%
Student > Master 22 9%
Student > Doctoral Student 13 5%
Other 37 15%
Unknown 25 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 86 34%
Agricultural and Biological Sciences 84 33%
Physics and Astronomy 17 7%
Computer Science 7 3%
Chemistry 5 2%
Other 23 9%
Unknown 32 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2018.
All research outputs
#4,326,263
of 16,530,923 outputs
Outputs from Febs Letters
#3,522
of 12,656 outputs
Outputs of similar age
#60,336
of 238,857 outputs
Outputs of similar age from Febs Letters
#10
of 80 outputs
Altmetric has tracked 16,530,923 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 12,656 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,857 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.