| Title |
The 4D nucleome: Evidence for a dynamic nuclear landscape based on co‐aligned active and inactive nuclear compartments
|
|---|---|
| Published in |
Febs Letters, May 2015
|
| DOI | 10.1016/j.febslet.2015.05.037 |
| Pubmed ID | |
| Authors |
Thomas Cremer, Marion Cremer, Barbara Hübner, Hilmar Strickfaden, Daniel Smeets, Jens Popken, Michael Sterr, Yolanda Markaki, Karsten Rippe, Christoph Cremer |
| Abstract |
Recent methodological advancements in microscopy and DNA sequencing-based methods provide unprecedented new insights into the spatio-temporal relationships between chromatin and functional nuclear machineries. We discuss a model of functional nuclear organization derived mostly from electron and super-resolved fluorescence microscopy studies. It is based on two spatially co-aligned, active and inactive nuclear compartments (ANC and INC). The INC comprises the compact, transcriptionally inactive core of chromatin domain clusters (CDCs). The ANC is formed by the transcriptionally active periphery of CDCs, called the perichromatin region (PR), and the interchromatin compartment (IC). The IC is connected to nuclear pores and serves nuclear import and export functions. The ANC is the major site of RNA synthesis. It is highly enriched in epigenetic marks for transcriptionally competent chromatin and RNA Polymerase II. Marks for silent chromatin are enriched in the INC. Multi-scale cross-correlation spectroscopy suggests that nuclear architecture resembles a random obstacle network for diffusing proteins. An increased dwell time of proteins and protein complexes within the ANC may help to limit genome scanning by factors or factor complexes to DNA exposed within the ANC. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| France | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | <1% |
| Czechia | 2 | <1% |
| United States | 2 | <1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Japan | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 282 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 72 | 25% |
| Researcher | 65 | 22% |
| Student > Bachelor | 34 | 12% |
| Student > Master | 24 | 8% |
| Student > Doctoral Student | 15 | 5% |
| Other | 44 | 15% |
| Unknown | 38 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 98 | 34% |
| Agricultural and Biological Sciences | 87 | 30% |
| Physics and Astronomy | 18 | 6% |
| Computer Science | 8 | 3% |
| Medicine and Dentistry | 7 | 2% |
| Other | 30 | 10% |
| Unknown | 44 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2023.
All research outputs
#6,761,242
of 25,394,764 outputs
Outputs from Febs Letters
#4,447
of 14,379 outputs
Outputs of similar age
#73,179
of 280,122 outputs
Outputs of similar age from Febs Letters
#21
of 110 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 14,379 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,122 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.