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pH-neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury

Overview of attention for article published in The Laryngoscope, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 4,306)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Readers on

mendeley
54 Mendeley
Title
pH-neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury
Published in
The Laryngoscope, June 2018
DOI 10.1002/lary.27312
Pubmed ID
Authors

Rachel R. Anfang, Kris R. Jatana, Rebecca L. Linn, Keith Rhoades, Jared Fry, Ian N. Jacobs

Abstract

Ingestion of button batteries (BB) can rapidly lead to caustic esophageal injury in infants and children, resulting in significant morbidity and mortality. To identify novel mitigation strategies, we tested common weakly acidic household beverages, viscous liquids, and Carafate® for their ability to act as protective esophageal irrigations until endoscopic removal of the BB. Cadaveric and live animal model. Apple juice, orange juice, Gatorade®, POWERADE®, pure honey, pure maple syrup, and Carafate® were screened using a 3 V lithium (3 V-CR2032) BB on cadaveric porcine esophagus. The most promising in vitro options were tested against a saline control in live American Yorkshire piglets with anode-facing placement of the BB on the posterior wall of the proximal esophagus for 60 minutes. BB voltage and tissue pH were measured before battery placement and after removal. The 10 mL irrigations occurred every 10 minutes from t = 5 minutes. Gross and histologic assessment was performed on the esophagus of piglets euthanized 7 ± 0.5 days following BB exposure. Honey and Carafate® demonstrated to a significant degree the most protective effects in vitro and in vivo. Both neutralized the tissue pH increase and created more localized and superficial injuries; observed in vivo was a decrease in both full-thickness injury (i.e., shallower depths of necrotic and granulation tissue) and outward extension of injury in the deep muscle beyond surface ulcer margins (P < .05). In the crucial period between BB ingestion and endoscopic removal, early and frequent ingestion of honey in the household setting and Carafate® in the clinical setting has the potential to reduce injury severity and improve patient outcomes. NA Laryngoscope, 2018.

Twitter Demographics

The data shown below were collected from the profiles of 242 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Other 11 20%
Student > Doctoral Student 8 15%
Student > Bachelor 7 13%
Student > Postgraduate 5 9%
Professor > Associate Professor 5 9%
Other 14 26%
Unknown 4 7%
Readers by discipline Count As %
Medicine and Dentistry 33 61%
Nursing and Health Professions 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Philosophy 1 2%
Agricultural and Biological Sciences 1 2%
Other 3 6%
Unknown 10 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 517. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2020.
All research outputs
#21,030
of 15,628,316 outputs
Outputs from The Laryngoscope
#3
of 4,306 outputs
Outputs of similar age
#881
of 279,632 outputs
Outputs of similar age from The Laryngoscope
#1
of 51 outputs
Altmetric has tracked 15,628,316 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,306 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.