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Inhibition of pre‐existing natural periodontitis in non‐human primates by a locally administered peptide inhibitor of complement C3

Overview of attention for article published in Journal of Clinical Periodontology, March 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 2,289)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
33 news outlets
blogs
1 blog
twitter
1 X user

Citations

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55 Dimensions

Readers on

mendeley
54 Mendeley
Title
Inhibition of pre‐existing natural periodontitis in non‐human primates by a locally administered peptide inhibitor of complement C3
Published in
Journal of Clinical Periodontology, March 2016
DOI 10.1111/jcpe.12507
Pubmed ID
Authors

Tomoki Maekawa, Ruel A Briones, Ranillo R G Resuello, Joel V Tuplano, Evlambia Hajishengallis, Tetsuhiro Kajikawa, Sophia Koutsogiannaki, Cristina A G Garcia, Daniel Ricklin, John D Lambris, George Hajishengallis

Abstract

Human periodontitis is associated with overactivation of complement, which is triggered by different mechanisms converging on C3, the central hub of the system. We assessed whether the C3 inhibitor Cp40 inhibits naturally-occurring periodontitis in non-human primates. Non-human primates with chronic periodontitis were intra-gingivally injected with Cp40 either once (5 animals) or three times (10 animals) weekly for six weeks followed by a 6-week follow-up period. Clinical periodontal examinations and collection of gingival crevicular fluid and biopsies of gingiva and bone were performed at baseline and during the study. A one-way repeated measures ANOVA was used for data analysis. Whether administered once or three times weekly, Cp40 caused a significant reduction in clinical indices that measure periodontal inflammation (gingival index and bleeding on probing), tissue destruction (probing pocket depth and clinical attachment level) or tooth mobility. These clinical changes were associated with significantly reduced levels of pro-inflammatory mediators and decreased numbers of osteoclasts in bone biopsies. The protective effects of Cp40 persisted, albeit at reduced efficacy, for at least six weeks following drug discontinuation. Cp40 inhibits pre-existing chronic periodontal inflammation and osteoclastogenesis in non-human primates, suggesting a novel adjunctive anti-inflammatory therapy for treating human periodontitis. This article is protected by copyright. All rights reserved.

X Demographics

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Bosnia and Herzegovina 1 2%
Czechia 1 2%
Unknown 51 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 17%
Other 5 9%
Student > Doctoral Student 5 9%
Student > Postgraduate 5 9%
Student > Bachelor 4 7%
Other 10 19%
Unknown 16 30%
Readers by discipline Count As %
Medicine and Dentistry 25 46%
Biochemistry, Genetics and Molecular Biology 3 6%
Agricultural and Biological Sciences 3 6%
Immunology and Microbiology 2 4%
Economics, Econometrics and Finance 1 2%
Other 3 6%
Unknown 17 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 247. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2021.
All research outputs
#150,470
of 25,394,764 outputs
Outputs from Journal of Clinical Periodontology
#11
of 2,289 outputs
Outputs of similar age
#2,620
of 312,987 outputs
Outputs of similar age from Journal of Clinical Periodontology
#1
of 32 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,289 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.