↓ Skip to main content

Wiley Online Library

Inhibition of pre‐existing natural periodontitis in non‐human primates by a locally administered peptide inhibitor of complement C3

Overview of attention for article published in Journal of Clinical Periodontology, January 2016
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 774)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
24 news outlets
blogs
1 blog
twitter
1 tweeter

Readers on

mendeley
12 Mendeley
Title
Inhibition of pre‐existing natural periodontitis in non‐human primates by a locally administered peptide inhibitor of complement C3
Published in
Journal of Clinical Periodontology, January 2016
DOI 10.1111/jcpe.12507
Pubmed ID
Authors

Maekawa, Tomoki, Briones, Ruel A., Resuello, Ranillo R.G., Tuplano, Joel V., Hajishengallis, Evlambia, Kajikawa, Tetsuhiro, Koutsogiannaki, Sophia, Garcia, Cristina A.G., Ricklin, Daniel, Lambris, John D., Hajishengallis, George, Briones, Ruel A, Resuello, Ranillo R G, Tuplano, Joel V, Garcia, Cristina A G, Lambris, John D

Abstract

Human periodontitis is associated with overactivation of complement, which is triggered by different mechanisms converging on C3, the central hub of the system. We assessed whether the C3 inhibitor Cp40 inhibits naturally-occurring periodontitis in non-human primates. Non-human primates with chronic periodontitis were intra-gingivally injected with Cp40 either once (5 animals) or three times (10 animals) weekly for six weeks followed by a 6-week follow-up period. Clinical periodontal examinations and collection of gingival crevicular fluid and biopsies of gingiva and bone were performed at baseline and during the study. A one-way repeated measures ANOVA was used for data analysis. Whether administered once or three times weekly, Cp40 caused a significant reduction in clinical indices that measure periodontal inflammation (gingival index and bleeding on probing), tissue destruction (probing pocket depth and clinical attachment level) or tooth mobility. These clinical changes were associated with significantly reduced levels of pro-inflammatory mediators and decreased numbers of osteoclasts in bone biopsies. The protective effects of Cp40 persisted, albeit at reduced efficacy, for at least six weeks following drug discontinuation. Cp40 inhibits pre-existing chronic periodontal inflammation and osteoclastogenesis in non-human primates, suggesting a novel adjunctive anti-inflammatory therapy for treating human periodontitis. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 8%
Bosnia and Herzegovina 1 8%
Czech Republic 1 8%
Unknown 9 75%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 50%
Student > Postgraduate 2 17%
Student > Ph. D. Student 2 17%
Student > Doctoral Student 2 17%
Readers by discipline Count As %
Medicine and Dentistry 9 75%
Biochemistry, Genetics and Molecular Biology 2 17%
Agricultural and Biological Sciences 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 190. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2016.
All research outputs
#29,346
of 7,458,268 outputs
Outputs from Journal of Clinical Periodontology
#5
of 774 outputs
Outputs of similar age
#2,372
of 319,679 outputs
Outputs of similar age from Journal of Clinical Periodontology
#1
of 35 outputs
Altmetric has tracked 7,458,268 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 774 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.