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GATA6 regulates aging of human mesenchymal stem/stromal cells

Overview of attention for article published in Stem Cells, November 2020
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#14 of 3,913)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Citations

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Readers on

mendeley
37 Mendeley
Title
GATA6 regulates aging of human mesenchymal stem/stromal cells
Published in
Stem Cells, November 2020
DOI 10.1002/stem.3297
Pubmed ID
Authors

Hongli Jiao, Brian E. Walczak, Ming-Song Lee, Madeleine E. Lemieux, Wan-Ju Li

Abstract

Cellular reprogramming forcing the expression of pluripotency markers can reverse aging of cells but how molecular mechanisms through which reprogrammed cells alter aging-related cellular activities still remain largely unclear. In this study, we reprogrammed human synovial fluid-derived mesenchymal stem cells (MSCs) into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation. Using the parental and reprogrammed MSCs as control nonrejuvenated and rejuvenated cells, respectively, for comparative analysis, we found that aging-related activities were greatly reduced in reprogrammed MSCs compared with those in their parental lines, indicating reversal of cell aging. Global transcriptome analysis revealed differences in activities of regulatory networks associated with inflammation and proliferation. Mechanistically, we demonstrated that, compared with control cells, the expression of GATA binding protein 6 (GATA6) in reprogrammed cells was attenuated, resulting in an increase in the activity of sonic hedgehog signaling and the expression level of downstream forkhead box P1 (FOXP1), in turn ameliorating cellular hallmarks of aging. Lower levels of GATA6 expression were also found in cells harvested from younger mice or lower passage cultures. Our findings suggest that GATA6 is a critical regulator increased in aged MSCs that controls the downstream sonic hedgehog signaling and FOXP1 pathway to modulate cellular senescence and aging-related activities.

Twitter Demographics

The data shown below were collected from the profiles of 45 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 16%
Student > Bachelor 4 11%
Student > Master 4 11%
Student > Ph. D. Student 3 8%
Student > Doctoral Student 2 5%
Other 6 16%
Unknown 12 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 32%
Unspecified 2 5%
Agricultural and Biological Sciences 2 5%
Medicine and Dentistry 2 5%
Business, Management and Accounting 1 3%
Other 2 5%
Unknown 16 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 184. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2021.
All research outputs
#181,948
of 23,002,898 outputs
Outputs from Stem Cells
#14
of 3,913 outputs
Outputs of similar age
#5,584
of 506,329 outputs
Outputs of similar age from Stem Cells
#2
of 33 outputs
Altmetric has tracked 23,002,898 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,913 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 506,329 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.