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Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors

Overview of attention for article published in Angewandte Chemie. International Edition, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 42,616)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
29 news outlets
blogs
6 blogs
twitter
3 tweeters
patent
8 patents
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
110 Dimensions

Readers on

mendeley
180 Mendeley
Title
Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors
Published in
Angewandte Chemie. International Edition, August 2016
DOI 10.1002/anie.201606123
Pubmed ID
Authors

Piyush K. Jain, Vyas Ramanan, Arnout G. Schepers, Nisha S. Dalvie, Apekshya Panda, Heather E. Fleming, Sangeeta N. Bhatia

Abstract

The ability to remotely trigger CRISPR/Cas9 activity would enable new strategies to study cellular events with greater precision and complexity. In this work, we have developed a method to photocage the activity of the guide RNA called "CRISPR-plus" (CRISPR-precise light-mediated unveiling of sgRNAs). The photoactivation capability of our CRISPR-plus method is compatible with the simultaneous targeting of multiple DNA sequences and supports numerous modifications that can enable guide RNA labeling for use in imaging and mechanistic investigations.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 179 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 44 24%
Researcher 30 17%
Student > Master 27 15%
Student > Bachelor 16 9%
Student > Doctoral Student 14 8%
Other 25 14%
Unknown 24 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 52 29%
Chemistry 35 19%
Agricultural and Biological Sciences 30 17%
Medicine and Dentistry 11 6%
Engineering 11 6%
Other 9 5%
Unknown 32 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 268. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2022.
All research outputs
#97,326
of 21,446,675 outputs
Outputs from Angewandte Chemie. International Edition
#21
of 42,616 outputs
Outputs of similar age
#2,335
of 287,368 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#2
of 881 outputs
Altmetric has tracked 21,446,675 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 42,616 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,368 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 881 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.