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Spermatozoa from normozoospermic fertile and infertile individuals convey a distinct miRNA cargo

Overview of attention for article published in Andrology, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
70 Mendeley
Summary Blogs Twitter Dimensions citations
Title
Spermatozoa from normozoospermic fertile and infertile individuals convey a distinct miRNA cargo
Published in
Andrology, September 2016
DOI 10.1111/andr.12276
Pubmed ID
27676136
Authors

A. Salas-Huetos, J. Blanco, F. Vidal, M. Grossmann, M. C. Pons, N. Garrido, E. Anton

Abstract

Deciphering the underlying causes of idiopathic male infertility is one of the main challenges in reproductive medicine. This is especially relevant in infertile patients displaying normal seminal parameters and no urogenital or genetic abnormalities. In these cases, the search for additional sperm biomarkers is of high interest. This study was aimed to determine the implications of the sperm miRNA expression profiles in the reproductive capacity of normozoospermic infertile individuals. The expression level of 736 miRNAs was evaluated in spermatozoa from eight normozoospermic infertile males using TaqMan(®) qRT-PCR. Results were contrasted with data from 10 control normozoospermic fertile individuals analyzed under the same conditions. Clustering analysis of miRNA expression data separated the individuals according to their fertility condition (fertile and infertile). Fifty-seven miRNAs were differentially expressed (DE-miRNAs) between populations; 20 of them was regulated by a host gene promoter that in three cases comprised genes involved in fertility. The predicted targets of the DE-miRNAs (n = 8,606) unveiled a significant enrichment of biological processes related to embryonic morphogenesis and chromatin modification. Normozoospermic infertile individuals exhibit a specific sperm miRNA expression profile clearly differentiated from normozoospermic fertile individuals. This miRNA cargo has potential implications in the individuals' reproductive competence.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 19%
Student > Master 12 17%
Researcher 9 13%
Student > Bachelor 7 10%
Student > Doctoral Student 5 7%
Other 13 19%
Unknown 11 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 29%
Agricultural and Biological Sciences 12 17%
Medicine and Dentistry 11 16%
Unspecified 1 1%
Nursing and Health Professions 1 1%
Other 6 9%
Unknown 19 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2016.
All research outputs
#3,641,409
of 22,889,074 outputs
Outputs from Andrology
#159
of 931 outputs
Outputs of similar age
#61,843
of 322,819 outputs
Outputs of similar age from Andrology
#4
of 28 outputs
Altmetric has tracked 22,889,074 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 931 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.7. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,819 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.

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