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Spermatozoa from normozoospermic fertile and infertile individuals convey a distinct miRNA cargo

Overview of attention for article published in Andrology, September 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

blogs
1 blog
twitter
2 X users

Citations

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53 Dimensions

Readers on

mendeley
78 Mendeley
Title
Spermatozoa from normozoospermic fertile and infertile individuals convey a distinct miRNA cargo
Published in
Andrology, September 2016
DOI 10.1111/andr.12276
Pubmed ID
Authors

A. Salas‐Huetos, J. Blanco, F. Vidal, M. Grossmann, M. C. Pons, N. Garrido, E. Anton

Abstract

Deciphering the underlying causes of idiopathic male infertility is one of the main challenges in reproductive medicine. This is especially relevant in infertile patients displaying normal seminal parameters and no urogenital or genetic abnormalities. In these cases, the search for additional sperm biomarkers is of high interest. This study was aimed to determine the implications of the sperm miRNA expression profiles in the reproductive capacity of normozoospermic infertile individuals. The expression level of 736 miRNAs was evaluated in spermatozoa from eight normozoospermic infertile males using TaqMan(®) qRT-PCR. Results were contrasted with data from 10 control normozoospermic fertile individuals analyzed under the same conditions. Clustering analysis of miRNA expression data separated the individuals according to their fertility condition (fertile and infertile). Fifty-seven miRNAs were differentially expressed (DE-miRNAs) between populations; 20 of them was regulated by a host gene promoter that in three cases comprised genes involved in fertility. The predicted targets of the DE-miRNAs (n = 8,606) unveiled a significant enrichment of biological processes related to embryonic morphogenesis and chromatin modification. Normozoospermic infertile individuals exhibit a specific sperm miRNA expression profile clearly differentiated from normozoospermic fertile individuals. This miRNA cargo has potential implications in the individuals' reproductive competence.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 77 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 17%
Student > Master 12 15%
Researcher 10 13%
Student > Bachelor 8 10%
Student > Doctoral Student 6 8%
Other 14 18%
Unknown 15 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 27%
Agricultural and Biological Sciences 13 17%
Medicine and Dentistry 11 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Nursing and Health Professions 1 1%
Other 6 8%
Unknown 25 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2016.
All research outputs
#3,989,426
of 24,451,065 outputs
Outputs from Andrology
#184
of 999 outputs
Outputs of similar age
#63,557
of 328,730 outputs
Outputs of similar age from Andrology
#4
of 28 outputs
Altmetric has tracked 24,451,065 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 999 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,730 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.