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Gold-Triggered Uncaging Chemistry in Living Systems

Overview of attention for article published in Angewandte Chemie. International Edition, August 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#6 of 33,077)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
43 news outlets
blogs
2 blogs
twitter
38 tweeters
facebook
6 Facebook pages
reddit
1 Redditor
video
1 video uploader

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
89 Mendeley
Title
Gold-Triggered Uncaging Chemistry in Living Systems
Published in
Angewandte Chemie. International Edition, August 2017
DOI 10.1002/anie.201705609
Pubmed ID
Authors

Ana M. Pérez-López, Belén Rubio-Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd-Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti-Broceta

Abstract

Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

Twitter Demographics

The data shown below were collected from the profiles of 38 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 89 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 31%
Student > Master 12 13%
Student > Bachelor 8 9%
Researcher 8 9%
Professor 7 8%
Other 17 19%
Unknown 9 10%
Readers by discipline Count As %
Chemistry 54 61%
Agricultural and Biological Sciences 7 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Medicine and Dentistry 4 4%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 6 7%
Unknown 10 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 375. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2019.
All research outputs
#32,262
of 14,370,924 outputs
Outputs from Angewandte Chemie. International Edition
#6
of 33,077 outputs
Outputs of similar age
#1,538
of 263,981 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#1
of 817 outputs
Altmetric has tracked 14,370,924 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,077 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,981 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 817 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.