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| Title |
Gold‐Triggered Uncaging Chemistry in Living Systems
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, August 2017
|
| DOI | 10.1002/anie.201705609 |
| Pubmed ID | |
| Authors |
Ana M. Pérez‐López, Belén Rubio‐Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd‐Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti‐Broceta |
| Abstract |
Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 15% |
| Saudi Arabia | 3 | 9% |
| Germany | 2 | 6% |
| Algeria | 1 | 3% |
| Mauritius | 1 | 3% |
| United Arab Emirates | 1 | 3% |
| India | 1 | 3% |
| Iraq | 1 | 3% |
| Russia | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 16 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 67% |
| Scientists | 10 | 30% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 156 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 27% |
| Student > Master | 22 | 14% |
| Student > Bachelor | 17 | 11% |
| Researcher | 15 | 10% |
| Student > Doctoral Student | 8 | 5% |
| Other | 26 | 17% |
| Unknown | 26 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 87 | 56% |
| Agricultural and Biological Sciences | 8 | 5% |
| Biochemistry, Genetics and Molecular Biology | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Medicine and Dentistry | 5 | 3% |
| Other | 15 | 10% |
| Unknown | 27 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 361. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2020.
All research outputs
#94,766
of 26,597,648 outputs
Outputs from Angewandte Chemie. International Edition
#17
of 52,768 outputs
Outputs of similar age
#2,065
of 333,508 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#2
of 807 outputs
Altmetric has tracked 26,597,648 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 52,768 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,508 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 807 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.