Report for: Gold‐Triggered Uncaging Chemistry in Living Systems

Title	Gold‐Triggered Uncaging Chemistry in Living Systems
Published in	Angewandte Chemie. International Edition, August 2017
DOI	10.1002/anie.201705609
Pubmed ID	28699691
Authors	Ana M. Pérez‐López, Belén Rubio‐Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd‐Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti‐Broceta
Abstract	Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

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Twitter Demographics

The data shown below were collected from the profiles of 34 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United Kingdom	7	21%
Germany	4	12%
Saudi Arabia	3	9%
United States	2	6%
Mauritius	1	3%
Russia	1	3%
Australia	1	3%
Iraq	1	3%
Algeria	1	3%
Other	2	6%
Unknown	11	32%

Demographic breakdown

Type	Count	As %
Members of the public	23	68%
Scientists	10	29%
Practitioners (doctors, other healthcare professionals)	1	3%

Mendeley readers

The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	136	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	37	27%
Student > Master	20	15%
Student > Bachelor	16	12%
Researcher	13	10%
Student > Doctoral Student	8	6%
Other	26	19%
Unknown	16	12%

Readers by discipline	Count	As %
Chemistry	82	60%
Agricultural and Biological Sciences	8	6%
Pharmacology, Toxicology and Pharmaceutical Science	7	5%
Biochemistry, Genetics and Molecular Biology	5	4%
Medicine and Dentistry	5	4%
Other	12	9%
Unknown	17	13%

Attention Score in Context

This research output has an Altmetric Attention Score of 369. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2020.

All research outputs

#66,140

of 22,113,391 outputs

Outputs from Angewandte Chemie. International Edition

#16

of 43,537 outputs

Outputs of similar age

#1,758

of 284,278 outputs

Outputs of similar age from Angewandte Chemie. International Edition

of 815 outputs

Altmetric has tracked 22,113,391 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 43,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 99% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,278 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.

We're also able to compare this research output to 815 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.

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Gold‐Triggered Uncaging Chemistry in Living Systems

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Geographical breakdown

Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context