Report for: Gold-Triggered Uncaging Chemistry in Living Systems

Title	Gold-Triggered Uncaging Chemistry in Living Systems
Published in	Angewandte Chemie. International Edition, August 2017
DOI	10.1002/anie.201705609
Pubmed ID	28699691
Authors	Ana M. Pérez-López, Belén Rubio-Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd-Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti-Broceta
Abstract	Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

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Twitter Demographics

The data shown below were collected from the profiles of 38 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United Kingdom	6	16%
Germany	5	13%
Saudi Arabia	3	8%
Spain	2	5%
Mauritius	1	3%
Australia	1	3%
Russia	1	3%
Netherlands	1	3%
Algeria	1	3%
Other	2	5%
Unknown	15	39%

Demographic breakdown

Type	Count	As %
Members of the public	26	68%
Scientists	10	26%
Practitioners (doctors, other healthcare professionals)	2	5%

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	89	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	28	31%
Student > Master	12	13%
Student > Bachelor	8	9%
Researcher	8	9%
Professor	7	8%
Other	17	19%
Unknown	9	10%

Readers by discipline	Count	As %
Chemistry	54	61%
Agricultural and Biological Sciences	7	8%
Pharmacology, Toxicology and Pharmaceutical Science	5	6%
Medicine and Dentistry	4	4%
Biochemistry, Genetics and Molecular Biology	3	3%
Other	6	7%
Unknown	10	11%

Attention Score in Context

This research output has an Altmetric Attention Score of 375. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2019.

All research outputs

#32,262

of 14,370,924 outputs

Outputs from Angewandte Chemie. International Edition

of 33,077 outputs

Outputs of similar age

#1,538

of 263,981 outputs

Outputs of similar age from Angewandte Chemie. International Edition

of 817 outputs

Altmetric has tracked 14,370,924 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 33,077 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 99% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,981 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.

We're also able to compare this research output to 817 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.

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Gold-Triggered Uncaging Chemistry in Living Systems

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Twitter Demographics

Geographical breakdown

Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context