Title |
Gold‐Triggered Uncaging Chemistry in Living Systems
|
---|---|
Published in |
Angewandte Chemie. International Edition, August 2017
|
DOI | 10.1002/anie.201705609 |
Pubmed ID | |
Authors |
Ana M. Pérez‐López, Belén Rubio‐Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd‐Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti‐Broceta |
Abstract |
Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 6 | 18% |
Germany | 4 | 12% |
Saudi Arabia | 3 | 9% |
United States | 2 | 6% |
Mauritius | 1 | 3% |
Russia | 1 | 3% |
United Arab Emirates | 1 | 3% |
Iraq | 1 | 3% |
Algeria | 1 | 3% |
Other | 2 | 6% |
Unknown | 11 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 22 | 67% |
Scientists | 10 | 30% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 152 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 42 | 28% |
Student > Master | 22 | 14% |
Student > Bachelor | 17 | 11% |
Researcher | 13 | 9% |
Student > Doctoral Student | 8 | 5% |
Other | 27 | 18% |
Unknown | 23 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 86 | 57% |
Agricultural and Biological Sciences | 8 | 5% |
Biochemistry, Genetics and Molecular Biology | 7 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Medicine and Dentistry | 5 | 3% |
Other | 15 | 10% |
Unknown | 24 | 16% |