Report for: Gold‐Triggered Uncaging Chemistry in Living Systems

Title	Gold‐Triggered Uncaging Chemistry in Living Systems
Published in	Angewandte Chemie. International Edition, August 2017
DOI	10.1002/anie.201705609
Pubmed ID	28699691
Authors	Ana M. Pérez‐López, Belén Rubio‐Ruiz, Víctor Sebastián, Lloyd Hamilton, Catherine Adam, Thomas L. Bray, Silvia Irusta, Paul M. Brennan, Guy C. Lloyd‐Jones, Dirk Sieger, Jesús Santamaría, Asier Unciti‐Broceta
Abstract	Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

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Twitter Demographics

The data shown below were collected from the profiles of 36 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Geographical breakdown

Country	Count	As %
United Kingdom	7	19%
Germany	5	14%
Saudi Arabia	3	8%
Iraq	1	3%
Australia	1	3%
Mauritius	1	3%
Russia	1	3%
Algeria	1	3%
United States	1	3%
Other	3	8%
Unknown	12	33%

Demographic breakdown

Type	Count	As %
Members of the public	24	67%
Scientists	11	31%
Practitioners (doctors, other healthcare professionals)	1	3%

Mendeley readers

The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	140	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	36	26%
Student > Master	23	16%
Student > Bachelor	16	11%
Researcher	13	9%
Student > Doctoral Student	8	6%
Other	27	19%
Unknown	17	12%

Readers by discipline	Count	As %
Chemistry	84	60%
Agricultural and Biological Sciences	8	6%
Pharmacology, Toxicology and Pharmaceutical Science	7	5%
Biochemistry, Genetics and Molecular Biology	5	4%
Medicine and Dentistry	5	4%
Other	13	9%
Unknown	18	13%

Attention Score in Context

This research output has an Altmetric Attention Score of 371. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2020.

All research outputs

#59,104

of 21,112,644 outputs

Outputs from Angewandte Chemie. International Edition

#14

of 42,114 outputs

Outputs of similar age

#1,711

of 282,084 outputs

Outputs of similar age from Angewandte Chemie. International Edition

of 816 outputs

Altmetric has tracked 21,112,644 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 42,114 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 99% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,084 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.

We're also able to compare this research output to 816 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.

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Gold‐Triggered Uncaging Chemistry in Living Systems

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Twitter Demographics

Geographical breakdown

Demographic breakdown

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context