Title |
Degradation of Single‐Layer and Few‐Layer Graphene by Neutrophil Myeloperoxidase
|
---|---|
Published in |
Angewandte Chemie. International Edition, August 2018
|
DOI | 10.1002/anie.201806906 |
Pubmed ID | |
Authors |
Rajendra Kurapati, Sourav P. Mukherjee, Cristina Martín, George Bepete, Ester Vázquez, Alain Pénicaud, Bengt Fadeel, Alberto Bianco |
Abstract |
Biodegradability of graphene is one of the fundamental parameters determining the fate in vivo of this material. Here, two types of aqueous dispersible graphene, corresponding to single layer (SLG) and few layer graphene (FLG), devoid of either chemical functionalisation or stabilizing surfactants, were subjected to biodegradation by human myeloperoxidase (hMPO) mediated catalysis. Graphene biodegradation was also studied in the presence of activated, degranulating human neutrophils. The degradation of both FLG and SLG sheets was confirmed by Raman spectroscopy and electron microscopy analyses, leading to the conclusion that highly dispersed pristine graphene is not biopersistent. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 79 | 20% |
United States | 15 | 4% |
Spain | 4 | 1% |
Canada | 4 | 1% |
India | 3 | <1% |
Germany | 2 | <1% |
Kuwait | 2 | <1% |
United Kingdom | 2 | <1% |
Austria | 2 | <1% |
Other | 8 | 2% |
Unknown | 278 | 70% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 384 | 96% |
Scientists | 8 | 2% |
Practitioners (doctors, other healthcare professionals) | 4 | 1% |
Science communicators (journalists, bloggers, editors) | 1 | <1% |
Unknown | 2 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 115 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 19% |
Student > Ph. D. Student | 18 | 16% |
Student > Bachelor | 14 | 12% |
Student > Master | 12 | 10% |
Other | 5 | 4% |
Other | 16 | 14% |
Unknown | 28 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 21 | 18% |
Chemistry | 15 | 13% |
Materials Science | 11 | 10% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Medicine and Dentistry | 5 | 4% |
Other | 25 | 22% |
Unknown | 31 | 27% |