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Alu element‐containing RNAs maintain nucleolar structure and function

Overview of attention for article published in EMBO Journal, October 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
twitter
6 tweeters
facebook
1 Facebook page

Readers on

mendeley
74 Mendeley
citeulike
1 CiteULike
Title
Alu element‐containing RNAs maintain nucleolar structure and function
Published in
EMBO Journal, October 2015
DOI 10.15252/embj.201591458
Pubmed ID
Authors

Maïwen Caudron‐Herger, Teresa Pankert, Jeanette Seiler, Attila Németh, Renate Voit, Ingrid Grummt, Karsten Rippe, M. Caudron-Herger, T. Pankert, J. Seiler, A. Nemeth, R. Voit, I. Grummt, K. Rippe

Abstract

Non-coding RNAs play a key role in organizing the nucleus into functional subcompartments. By combining fluorescence microscopy and RNA deep-sequencing-based analysis, we found that RNA polymerase II transcripts originating from intronic Alu elements (aluRNAs) were enriched in the nucleolus. Antisense-oligo-mediated depletion of aluRNAs or drug-induced inhibition of RNA polymerase II activity disrupted nucleolar structure and impaired RNA polymerase I-dependent transcription of rRNA genes. In contrast, overexpression of a prototypic aluRNA sequence increased both nucleolus size and levels of pre-rRNA, suggesting a functional link between aluRNA, nucleolus integrity and pre-rRNA synthesis. Furthermore, we show that aluRNAs interact with nucleolin and target ectopic genomic loci to the nucleolus. Our study suggests an aluRNA-based mechanism that links RNA polymerase I and II activities and modulates nucleolar structure and rRNA production.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Germany 1 1%
France 1 1%
United Kingdom 1 1%
Denmark 1 1%
United States 1 1%
Netherlands 1 1%
Unknown 67 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 34%
Student > Ph. D. Student 16 22%
Student > Doctoral Student 8 11%
Professor > Associate Professor 7 9%
Student > Master 5 7%
Other 13 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 40 54%
Biochemistry, Genetics and Molecular Biology 24 32%
Unspecified 3 4%
Neuroscience 3 4%
Medicine and Dentistry 3 4%
Other 1 1%

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2015.
All research outputs
#219,742
of 7,419,627 outputs
Outputs from EMBO Journal
#82
of 4,321 outputs
Outputs of similar age
#12,451
of 239,183 outputs
Outputs of similar age from EMBO Journal
#13
of 51 outputs
Altmetric has tracked 7,419,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,321 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,183 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.