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An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins

Overview of attention for article published in Cellular Microbiology, September 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 tweeters

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1 Mendeley
Title
An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins
Published in
Cellular Microbiology, September 2018
DOI 10.1111/cmi.12949
Pubmed ID
Authors

Azad Eshghi, Robert A. Gaultney, Patrick England, Sébastien Brûlé, Isabelle Miras, Hiromi Sato, Jenifer Coburn, Jacques Bellalou, Tara J. Moriarty, Ahmed Haouz, Mathieu Picardeau

Abstract

Pathogenic Leptospira bacteria are the causative agents of leptospirosis, a zoonotic disease affecting animals and humans worldwide. These pathogenic species have the ability to rapidly cross host tissue barriers by a yet unknown mechanism. A comparative analysis of pathogens and saprophytes revealed a higher abundance of genes encoding proteins with Leucine Rich Repeat (LRR) domains in the genomes of pathogens. In other bacterial pathogens, proteins with LRR domains have been shown to be involved in mediating host cell attachment and invasion. One protein from the pathogenic species L. interrogans, LIC10831, has been previously analyzed via X-ray crystallography, with findings suggesting it may be an important bacterial adhesin. Herein we show that LIC10831 elicits an antibody response in infected animals, is actively secreted by the bacterium, and binds human E-and VE-cadherins. These results provide biochemical and cellular evidence of LRR protein-mediated host-pathogen interactions and identify a new multi-receptor binding protein from this infectious Leptospira species.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Professor 1 100%
Readers by discipline Count As %
Medicine and Dentistry 1 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2018.
All research outputs
#6,576,897
of 12,266,041 outputs
Outputs from Cellular Microbiology
#673
of 1,162 outputs
Outputs of similar age
#110,784
of 250,048 outputs
Outputs of similar age from Cellular Microbiology
#8
of 14 outputs
Altmetric has tracked 12,266,041 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,162 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,048 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.