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Telomere dysfunction and chromothripsis

Overview of attention for article published in International Journal of Cancer, February 2016
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Mentioned by

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1 tweeter
facebook
1 Facebook page

Citations

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32 Dimensions

Readers on

mendeley
69 Mendeley
Title
Telomere dysfunction and chromothripsis
Published in
International Journal of Cancer, February 2016
DOI 10.1002/ijc.30033
Pubmed ID
Authors

Aurélie Ernst, David T.W. Jones, Kendra K. Maass, Agata Rode, Katharina I. Deeg, Billy Michael Chelliah Jebaraj, Andrey Korshunov, Volker Hovestadt, Michael A. Tainsky, Kristian W. Pajtler, Sebastian Bender, Sebastian Brabetz, Susanne Gröbner, Marcel Kool, Frauke Devens, Jennifer Edelmann, Cindy Zhang, Pedro Castelo-Branco, Uri Tabori, David Malkin, Karsten Rippe, Stephan Stilgenbauer, Stefan M. Pfister, Marc Zapatka, Peter Lichter

Abstract

Chromothripsis is a recently discovered form of genomic instability, characterized by tens to hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere dysfunction has been suggested to play a role in the initiation of this phenomenon, which occurs in a large number of tumor entities. Here, we show that telomere attrition can indeed lead to catastrophic genomic events, and that telomere patterns differ between cells analyzed before and after such genomic catastrophes. Telomere length and telomere stabilization mechanisms diverge between samples with and without chromothripsis in a given tumor subtype. Longitudinal analyses of the evolution of chromothriptic patterns identify either stable patterns between matched primary and relapsed tumors, or loss of the chromothriptic clone in the relapsed specimen. The absence of additional chromothriptic events occurring between the initial tumor and the relapsed tumor sample points to telomere stabilization after the initial chromothriptic event which prevents further shattering of the genome. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 1%
Belgium 1 1%
Unknown 67 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 22%
Student > Master 11 16%
Researcher 9 13%
Student > Bachelor 9 13%
Student > Doctoral Student 7 10%
Other 10 14%
Unknown 8 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 38%
Agricultural and Biological Sciences 15 22%
Medicine and Dentistry 12 17%
Computer Science 2 3%
Immunology and Microbiology 2 3%
Other 4 6%
Unknown 8 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
All research outputs
#9,349,062
of 12,177,359 outputs
Outputs from International Journal of Cancer
#7,629
of 8,806 outputs
Outputs of similar age
#222,669
of 347,492 outputs
Outputs of similar age from International Journal of Cancer
#103
of 175 outputs
Altmetric has tracked 12,177,359 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,806 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,492 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 175 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.