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Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir III Complex Conjugated to a Far‐Red Emitting Coumarin

Overview of attention for article published in Angewandte Chemie. International Edition, May 2019
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
twitter
24 tweeters

Citations

dimensions_citation
99 Dimensions

Readers on

mendeley
66 Mendeley
Title
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir III Complex Conjugated to a Far‐Red Emitting Coumarin
Published in
Angewandte Chemie. International Edition, May 2019
DOI 10.1002/anie.201901268
Pubmed ID
Authors

Vojtech Novohradsky, Anna Rovira, Cormac Hally, Alex Galindo, Gloria Vigueras, Albert Gandioso, Marie Svitelova, Roger Bresolí‐Obach, Hana Kostrhunova, Lenka Markova, Jana Kasparkova, Santi Nonell, José Ruiz, Viktor Brabec, Vicente Marchán

Abstract

Although cyclometalated Ir(III) complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation such as operability in the phototherapeutic window and ROS production efficiency and selectivity. In this work, we report a cyclometalated Ir(III) complex conjugated to a far-red emitting coumarin with highly favourable properties for cancer phototherapy. Ir(III)-COUPY was efficiently taken up by living HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after blue (161) and green (85) light irradiation, even under hypoxia. Importantly, a clear correlation between cell death and intracellular superoxide anion radicals' generation after visible light irradiation was demonstrated. By taking advantage of the rich photophysical properties of COUPY fluorophores and of the well-stablished anticancer activities of Ir(III) complexes, this strategy opens the door to novel fluorescent PDT agents with promising applications in theragnosis.

Twitter Demographics

The data shown below were collected from the profiles of 24 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 24%
Student > Bachelor 9 14%
Student > Master 5 8%
Other 4 6%
Researcher 3 5%
Other 11 17%
Unknown 18 27%
Readers by discipline Count As %
Chemistry 30 45%
Biochemistry, Genetics and Molecular Biology 6 9%
Unspecified 2 3%
Agricultural and Biological Sciences 2 3%
Environmental Science 1 2%
Other 4 6%
Unknown 21 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2020.
All research outputs
#1,188,630
of 19,247,573 outputs
Outputs from Angewandte Chemie. International Edition
#2,180
of 40,134 outputs
Outputs of similar age
#29,648
of 281,947 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#46
of 774 outputs
Altmetric has tracked 19,247,573 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 40,134 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,947 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 774 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.