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Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin

Overview of attention for article published in Angewandte Chemie. International Edition, April 2019
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

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1 news outlet
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24 X users

Citations

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148 Dimensions

Readers on

mendeley
82 Mendeley
Title
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin
Published in
Angewandte Chemie. International Edition, April 2019
DOI 10.1002/anie.201901268
Pubmed ID
Authors

Vojtech Novohradsky, Anna Rovira, Cormac Hally, Alex Galindo, Gloria Vigueras, Albert Gandioso, Marie Svitelova, Roger Bresolí‐Obach, Hana Kostrhunova, Lenka Markova, Jana Kasparkova, Santi Nonell, José Ruiz, Viktor Brabec, Vicente Marchán

Abstract

Although cyclometalated Ir(III) complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation such as operability in the phototherapeutic window and ROS production efficiency and selectivity. In this work, we report a cyclometalated Ir(III) complex conjugated to a far-red emitting coumarin with highly favourable properties for cancer phototherapy. Ir(III)-COUPY was efficiently taken up by living HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after blue (161) and green (85) light irradiation, even under hypoxia. Importantly, a clear correlation between cell death and intracellular superoxide anion radicals' generation after visible light irradiation was demonstrated. By taking advantage of the rich photophysical properties of COUPY fluorophores and of the well-stablished anticancer activities of Ir(III) complexes, this strategy opens the door to novel fluorescent PDT agents with promising applications in theragnosis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 82 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 21%
Student > Bachelor 10 12%
Other 6 7%
Student > Master 5 6%
Researcher 4 5%
Other 14 17%
Unknown 26 32%
Readers by discipline Count As %
Chemistry 32 39%
Biochemistry, Genetics and Molecular Biology 7 9%
Unspecified 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Agricultural and Biological Sciences 2 2%
Other 6 7%
Unknown 30 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2020.
All research outputs
#1,819,529
of 26,106,397 outputs
Outputs from Angewandte Chemie. International Edition
#3,163
of 51,376 outputs
Outputs of similar age
#39,703
of 367,819 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#50
of 780 outputs
Altmetric has tracked 26,106,397 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,376 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,819 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 780 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.