| Title |
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, April 2019
|
| DOI | 10.1002/anie.201901268 |
| Pubmed ID | |
| Authors |
Vojtech Novohradsky, Anna Rovira, Cormac Hally, Alex Galindo, Gloria Vigueras, Albert Gandioso, Marie Svitelova, Roger Bresolí‐Obach, Hana Kostrhunova, Lenka Markova, Jana Kasparkova, Santi Nonell, José Ruiz, Viktor Brabec, Vicente Marchán |
| Abstract |
Although cyclometalated Ir(III) complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation such as operability in the phototherapeutic window and ROS production efficiency and selectivity. In this work, we report a cyclometalated Ir(III) complex conjugated to a far-red emitting coumarin with highly favourable properties for cancer phototherapy. Ir(III)-COUPY was efficiently taken up by living HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after blue (161) and green (85) light irradiation, even under hypoxia. Importantly, a clear correlation between cell death and intracellular superoxide anion radicals' generation after visible light irradiation was demonstrated. By taking advantage of the rich photophysical properties of COUPY fluorophores and of the well-stablished anticancer activities of Ir(III) complexes, this strategy opens the door to novel fluorescent PDT agents with promising applications in theragnosis. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 13% |
| France | 2 | 8% |
| United States | 2 | 8% |
| United Kingdom | 2 | 8% |
| Brazil | 1 | 4% |
| Mexico | 1 | 4% |
| Canada | 1 | 4% |
| Unknown | 12 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 50% |
| Scientists | 11 | 46% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 22% |
| Student > Bachelor | 10 | 13% |
| Other | 6 | 8% |
| Student > Master | 5 | 6% |
| Researcher | 4 | 5% |
| Other | 12 | 15% |
| Unknown | 25 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 32 | 41% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Agricultural and Biological Sciences | 2 | 3% |
| Materials Science | 2 | 3% |
| Other | 5 | 6% |
| Unknown | 29 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2020.
All research outputs
#1,751,414
of 25,385,509 outputs
Outputs from Angewandte Chemie. International Edition
#3,098
of 50,006 outputs
Outputs of similar age
#39,309
of 364,535 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#50
of 781 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50,006 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,535 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 781 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.